Chip comparison
AMD Instinct MI250X vs NVIDIA GB300 (Blackwell Ultra)
Side-by-side specs
Straight from each vendor's datasheet. Winner in bold: higher throughput, memory, or transistor count; lower power draw or price. Sparse (2:4) throughput roughly doubles the FP8/INT8 numbers shown.
| Field | AMD Instinct MI250X | NVIDIA GB300 (Blackwell Ultra) |
|---|---|---|
| Process node | TSMC N6 | TSMC 4NP |
| TDP | 560 W | 1400 W |
| Memory | 128 GB HBM2e | 288 GB HBM3e |
| Memory bandwidth | 3,200 GB/s | 8,000 GB/s |
| FP16 (dense) | 383 TFLOPS | — |
| BF16 (dense) | 383 TFLOPS | — |
| FP8 (dense) | — | 5,000 TFLOPS |
| INT8 (dense) | 383 TOPS | — |
| Form factor | OAM | Superchip (Blackwell Ultra + Grace) |
| Announced | 2021-11-08 | 2025-03-18 |
| Released | 2022-06-01 | 2025-11-01 |
Robots running AMD Instinct MI250X
No robots publicly running it yet.
Robots running NVIDIA GB300 (Blackwell Ultra)
No robots publicly running it yet.
Data centers with AMD Instinct MI250X
No data centers publicly running it yet.
Data centers with NVIDIA GB300 (Blackwell Ultra)
Common questions
AMD Instinct MI250X vs NVIDIA GB300 (Blackwell Ultra): which is faster for training?
NVIDIA GB300 (Blackwell Ultra) has 13.05x the dense FP16/BF16 throughput of the other (AMD Instinct MI250X: 383 TFLOPS; NVIDIA GB300 (Blackwell Ultra): 5,000 TFLOPS). Real-world training speed also depends on memory bandwidth, interconnect, and software stack: see the spec diff for those inputs.
AMD Instinct MI250X vs NVIDIA GB300 (Blackwell Ultra): which has more memory?
NVIDIA GB300 (Blackwell Ultra) carries more HBM (AMD Instinct MI250X: 128 GB HBM2e; NVIDIA GB300 (Blackwell Ultra): 288 GB HBM3e). Memory capacity sets the largest model that fits on one chip without partitioning; memory bandwidth sets inference throughput.
AMD Instinct MI250X vs NVIDIA GB300 (Blackwell Ultra): which is more power-efficient?
Dense FP16/BF16 TFLOPS per watt: AMD Instinct MI250X 0.68 (383 ÷ 560 W); NVIDIA GB300 (Blackwell Ultra) 3.57 (5,000 ÷ 1400 W). NVIDIA GB300 (Blackwell Ultra) wins at the die level; system-level efficiency also depends on cooling and interconnect.
AMD Instinct MI250X vs NVIDIA GB300 (Blackwell Ultra): which is more widely used?
AMD Instinct MI250X: 0 robots and 0 data centers publicly running it. NVIDIA GB300 (Blackwell Ultra): 0 robots and 1 data center. Empty here means no operator has said publicly, not zero adoption in the market.
See also: every chip comparison · AMD Instinct MI250X full page · NVIDIA GB300 (Blackwell Ultra) full page.